Macrolide antibiotics like erythromycin,
azithromycin, chloramphenicol, lincomycine,
and clindamycin which are excreted
and detoxified by liver should be used with cautions in these patients. Tetracycline, Isoniazid and Rifampin have prolonged half life in patients with liver cirrhosis. Metronidazole ketocanozole, miconazole, fluconazole, itraconazole, and nitrofurantoin pyrazinamide should be used with caution.