Avastin and tarceva for lung cancer

Common Questions and Answers about Avastin and tarceva for lung cancer

tarceva

i'm from Italy and my father (64 years old) has lung cancer (adenocarcinoma) since june 2007 with multiple small cerebral metastasis. He had a radioterapy cycle (all head irradiation) and 6 chemotherapy cycle (cisplatinum+vinorelbine every 21 days last on january 2008). In febrary 2008 he had a pulmonary niggle and he was treated with heparin. At this moment, his cerebral situation is very good (just one small metastasi) and lung situation is stationary.
In 2005, he had Tarceva. In 2008 they discovered metastasis to the liver (3 lesions) and he underwent chemo again (I think Avastin) and he finished the treatment in March. The doctor said the tumors in both the lungs and liver were smaller. For the past 3 weeks he´s been vomiting, but sporadically. There is no pattern. It doesn´t matter if he eats lightly or heavily. Some days he vomits once, some days nothing. He went to see a Gastroenterologist. They did a sonogram...
Our oncologist would like to skip other standard chemo protocols and jump straight to Tarceva (after performing radiation on his hip) as he feels this will be easier on my dad given his age and cancer stage. I understand that the Tarceva is efficacious (average) for roughly up to 12 months in helping to limit tumour growth/spread. My questions are: Tarceva is typically used as a second line of therapy - is that d/t cost (i.e. is Tarceva considered 'better' than standard chemo protocols?)?
We are praying with you. God Bless you and your family. Stay positive.
Hi, Your concerns are valid. Lung cancer is afterall, the biggest cause of cancer mortality. For this post, I can only work with the stage information, your doctor likely has better estimates. Much of the answer here depends on how much the disease is affecting her daily living. If she stays in bed most of her waking hours, then treatment may only make an impact on symptom improvement. If she is able to maintain a fairly active lifestyle – then treatment may help extend survival .
One tumor shrunk the other two grew, and others did not change. He is now on Taxotere and Avastin. For the last two Ct scans the tumors have shrunk. The dr said he can go on maintanence. Take a break from the Taxotere. He has had 5, and just continue with the Avastin. My question. I keep reading about 4 -6 rounds of Taxotere. Does that mean that is all he can have, or if the tumors start growing again, he can have another 4 -6 rounds, or does he move to the next treatment, Tarceva? Thank you.
There is some concern, as this agent is indeed still being investigated. For use in lung cancer, there is some concern. While there is an agent called Avastin that has shown good results when used with Chemo for patients who are have never received chemo, whether this will also be true if the Avastin was given for those who finished initial course of chemo is not known.
The lymph nodes on the left side of the lung were effected and removed. He is receiving cisplatin and taxotere as his treatment. His brain scan, abdominal organs all were clear at the time of the diagnosis. Yesterday he had an abdominal ultrasound (not due to any complaints) which showed a 15 milimeter 'something" in the liver. He was sent for a CT scan later in the week, but I am just worried sick what this could be? Is it possible to develop new tumors DURING chemotherapy?
I am currently on Tarceva after two rounds of chemo apparently did no good and the cancer spread in my bones and spine. I was on Avastin, but I am coughing up blood, so I don't think they will be offering it to me anymore due to the possibility of hemmorhage. This is a really painful disease and I am really struggling mentally with it. I cannot live my life like before and a feel reduced to a burden on my family. I have no energy to walk and can only stand for a few minutes at a time.
One tumor shrunk the other two grew, and others did not change. He is now on Taxotere and Avastin. For the last two Ct scans the tumors have shrunk. The dr said he can go on maintanence. Take a break from the Taxotere. He has had 5, and just continue with the Avastin. My question. I keep reading about 4 -6 rounds of Taxotere. Does that mean that is all he can have, or if the tumors start growing again, he can have another 4 -6 rounds, or does he move to the next treatment, Tarceva? Thank you.
So, the plan is a 12 week course of chemotherapy and if it works well for me the possibility of radiotherapy later on and Tarceva too. So now I have to chose which drugs to go with and maybe I'm wrong but I'm thinking that if the Cisplatin works better in reducing the tumors I may have a better chance of the radiotherapy also working more effectively too.
In 2005, after Genentech announced success in using the colorectal cancer drug Avastin to treat breast and lung cancer, the company also said these patients would need twice the dose — doubling the price tag to $100,000 per year." "The debate has prompted drugmakers to acknowledge with surprising candor a final reason for the eye-popping price tags: These meds cost a lot because patients are willing to pay a lot for something that works so well.
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