Atorvastatin drug study

Common Questions and Answers about Atorvastatin drug study

lipitor

Simvastatin was chosen because it is now off patent, and is therefore now a much cheaper statin drug compared to the newer stronger varieties such as lipitor (atorvastatin).
This is the first clinical research study of BHT-3009. Laboratory studies have shown that BHT-3009 and atorvastatin given together alters the immune response to myelin basic protein and makes the response less harmful.
I was curious why the Harvard study picked atorvastatin when fluvastatin had been flagged as the most promising candidate. Here's what they have to say on statin selection and dosage. Doesn't look like they're at odds with the DDW study or the previous in-vitro results - just showing that the protocol may need fine-tuning. "The in vitro data clearly shows a difference in potency of the HMG-CoA reductase inhibitors.
In the best data we have looking at plaque effects of statins, the recently released REVERSAL study, looking at plaque size using IVUS therapy, high dose atorvastatin was shown to essenntially halt progression of plaque size compared with normal dose pravastatin. I'm not 100% sure if this correlates with differing enpoints, but in those with proven ateroma burden, I tend to use high dose atorvastain. The side effect profile in the study was the same.
Mikhailidis, MD, of University College London, and colleagues reported online in The Lancet. Their retrospective analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) trial showed a greater statin effect on cardiovascular risk reduction in these high-risk patients than in those with normal liver tests (P=0.0074).
54 AM ET LIPITOR DOES NOT PREVENT NARROWING IN HEART VALVE The popular cholesterol-reducing drug Lipitor made by Pfizer does not prevent obstruction of the heart valve that leads to the aorta, the body's largest artery, according to recent findings published in the New England Journal of Medicine.
Compared with placebo there was a 35% relative reduction of LDL-C in the atorvastatin group. The primary end point of the study (non fatal MI and a fatal Coronary Heart disease ) was significantly lower by 36 % in the statin group than in the placebo group. There were also significant reductions in secondary endpoints such as total coronary events by 29% and especially fatal and non-fatal strokes by 27%.
I remember reading a study here at MH about statins and HCV. I hope someone can find it. I'd like to give a copy to my heart doc.
They were very objective in presenting the facts about all the DMD's but most of the numbers I captured on paper relate to Copaxone, Shared Solutions' drug. They both feel strongly that it is not acceptable to do nothing in light of symptoms of CIS. In clinical trials with Copaxone to treat CIS, 42.9% of the patients who were given the placebo progressed to having CDMS. 24.7% of the copaxone treated test patients progressed to CDMS.
The deliverable at the completion of this initial study will be the identification of a drug that is ready to be moved from tissue culture to future animal studies.
Many patients respond well to this diet and end up sufficiently reducing blood cholesterol levels. Study data reinforce these benefits. For example, a 1998 Columbia University study examined 103 male and female patients of diverse ages and ethnic backgrounds and found that reducing dietary saturated fat directly affected blood cholesterol. For every 1 percent drop in saturated fat, the study showed a 1 percent lowering of LDL in patients.
But PPIs like Nexium (exomeprazole) and Prevacid (lansoprazole) have been shown to both block nutrient absorption and inhibit the production of necessary stomach acid, which can cause a host of other health problems. The U.S. Food and Drug Administration (FDA) has issued at least a dozen warnings about the dangers of PPIs, which include an increased risk of bacterial diarrhea, magnesium deficiency, and bone fractures (http://www.fda.gov).
As result of recent studies, the FDA is preparing to remove the threat of liver damage from the list of side effects. Also, the study being referred to above is the ENHANCE study that did not find that the addition of Zetia made Zocor more effective. In fact, ENHANCE showed that the addition of Zetia to Simvastatin showed no additional benefit.
I had always thought under 200 was properly effective, but there has been a push for further reduction below 200 as more favorable....I don't know if that originates from the drug companies or the medical community, but I am beginning to look skeptically at the matter...risk v. benefit.
It has a long half-life as it is not readily metabolized by the cytochrome P450 system. Furthermore, the drug is considered to be safe in patients with underlying aminotransferase elevation. A study by George and colleagues[17] evaluated whether blocking lipid synthesis via the use of rosuvastatin might interfere with some steps in HCV viral assembly or packaging and reduce HCV RNA levels in treatment-experienced hepatitis C patients.
4% increase in patients taking high dose atorvastatin. The overall consensus of this study was that high dose statin therapy can halt or slow the progression of obstructive coronary disease. In the absence of symptoms, usually we will repeat a stress in patients with known disease. Markers of arterial inflammation such as CRP can help identify patients whose disease might be active and who need more intensive monitoring and therapy.
I understand this is a relatively new medicine, is there any feedback on this drug yet? can i expect similar side effects as when i started the statin? should i wait until more info is available? thanks alot.
This is a lot, and most people don't need this much of a reduction, certainly that much of the powerful drug. You can get 5mg, but this is the lowest. It has been shown that 2.5mg lowers c-ldl by 40% and 1mg by 34%. Crestor studies showed that 1mg reduced c-ldl by the same level as 20-40mg of simvastatin. As the American Journal of cardiology stated, as levels of statins double, so does the frequency of liver damage. It also states why take more than your body needs.
The latest studies show that inflammation is an independent risk factor for heart disease that is much stronger than any measure of cholesterol.1 I cite a study of two statin drugs, atorvastatin and pravastatin, that was reported in the 2005 issue of The New England Journal of Medicine.
Gemfibrozil and Tricor are both fenofibrates. The warning applies to ALL statins and Fenofibrates, not just pravastatin. The general warning: "The combined use of TRICOR (a fenofibrate) and HMG-CoA reductase inhibitors (statins) should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.
Valid for credit through 12/01/2011 December 1, 2010 — A post hoc analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) study suggests that physicians should not let mildly to moderately abnormal liver test results stop them from using a statin in patients with coronary heart disease [1]. Statin therapy is not only safe in these patients, report investigators, but it significantly reduces the risk of cardiovascular events and improves liver-function tests.
It looks like a recent study also links h pylori infection with diabetes. Apprarently, something is not feeling right and I'm quite concerned. If you hsve been taking statins for a long time, could you please share your personal experience and observations? Thank you!
I tried a couple of statins again but had same reaction...back to RYR. Check out Duke University's latest study of RYR vs. statins...suprising to docs, not to naturopaths and younger doctors. Here's the best cholesterol fighting team: Fish Oil, Red Yeast Rice, CoQ10, 81mg Aspirin. Eat lots of fish high in Omega 3s (Salmon, Sardines), skinless chicken and green vegetables, exercise regularly. Keep red meat consumption to 8 oz. once every 10 days and limit cheese to almost nothing.
I believe you're speaking of Atorvastatin which is sold as Lipitor. Much depends on your numbers. Lipitor is one of the stronger statin drugs and is commonly used to reduce high levels of serum LDL. Lipitor has also been shown to have a minimal effect on raising HDL as well, but is primarily prescribed to individuals with high levels of LDL (over 130) or high total cholesterol (over 200) or people that have several risk factors for CAD along with high cholesterol levels.
Simvastatin (Zocor), a medication used to lower blood cholesterol, had a synergistic effect against hepatitis B virus (HBV) when combined with antiviral drugs in a laboratory study, researchers reported last month at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2009) in Boston. In another study, the diabetes drug rosiglitazone also demonstrated in vitro activity against HBV.
I take lipitor (atorvastatin) which is the one with the lowest recorded number of side effects. I have been taking 40mg for over three years with no problems at all and my cholesterol numbers are excellent. With the symptoms you describe you should get to your Doctor quickly to change over to another alternative because muscle damage can result which can end up being irreversible.
I have also seen reports stating that the more a person sleeps, the higher their cholesterol and the lower their good cholesterol. A study also showed how sleep devravation over a 5 day period reduced cholesterol levels. So, if we spit a statin pill, will it have the same desired effect? Everyone I know takes their statin in the evening, so I assume there is a reason for this backed up by research?
I'm told that Fluvastatin, a cholesterol-lowering drug, also reduces viral load. Anyone know about this?
Have past out and had lighted-headness on occasion in past. I take metoprolol, captopril, felodipine,atorvastatin, asprin, and several vitiams. I walk daily. My heart rate when I wake up is usually in the high 40's, walking usually it goes to about 88-94. Recently I've been trying exersice more. I've using a elliptical trainer. I can get my heart rate up to 122- 130 on this machine. I check my heart rate about every two or three minutes.
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