* On average, reductions of 25% to 36% were seen in peak concentration of the three drugs, when given
with boceprevir, along
with declines of 34% to 44% in exposure (area under the curve).
* Coadministration of ritonavir-boosted atazanavir did not alter the exposure of boceprevir, but giving it with lopinavir/ritonavir or darunavir/ritonavir decreased the exposure of boceprevir by 45% and 32%, respectively.