Atazanavir monotherapy

Common Questions and Answers about Atazanavir monotherapy

reyataz

446474 tn?1446347682 * Boceprevir reduced average trough concentrations of ritonavir-boosted atazanavir (Reyataz), lopinavir (Kaletra), and darunavir (Prezista) by 49%, 43% and 59%, respectively. * On average, reductions of 25% to 36% were seen in peak concentration of the three drugs, when given with boceprevir, along with declines of 34% to 44% in exposure (area under the curve).
250084 tn?1303307435 I am curious on this, reading other's tx's here. We know that a non reponder with Peg, Riba must extend, harder to achieve SVR, etc. but when one is noted as a non responder with monotherapy, is it, should it really be considered non responder? Being it's a different tx, and was usually not very successful. Not too sure I'd do 72 weeks due to that. Would the possibility of built resistance to interferon apply here?
2046312 tn?1360379600 The interaction has also been reported with atazanavir/ritonavir. A case series describes three patients who experienced excessive opiate effects of buprenorphine during concomitant antiretroviral therapy with atazanavir, ritonavir, and various nucleoside reverse transcriptase inhibitors. Two of the patients had been on their antiretroviral regimen for several months and reported doped-up feeling, dizziness, and feeling high following initiation of buprenorphine 8 mg/day.
Avatar f tn Willy: Well, first let me say that I am mighty surprised and disappointed. I had expected that the same response dynamic would simply continue evenly across all genotypes. --------------------------------- Why disappointed? Seems geno 2's fare better with Telaprevir than geno 1's and may be able to treat with monotherapy. As to geno 3's, it looks like only monotherapy didnt do well but maybe Im reading this study wrong.
Avatar m tn SB 9200 is the Company’s novel small molecule nucleic acid hybrid (SMNH) compound being developed as both monotherapy and combination therapy for the treatment of Hepatitis B (HBV) and other viral diseases. The first portion of the ACHIEVE trial is a Phase 2a placebo-controlled, sequential-cohort, double-blind trial to evaluate increasing doses of SB 9200 as monotherapy for 12 weeks followed by tenofovir disoproxil fumarate (marketed by Gilead Sciences, Inc.
Avatar f tn I have to ask: Was this your doctor's decision to treat you with monotherapy for this long ? Or did you push for it ? The reason I ask is I can't imagine what kind of logic the doctor employed to reach this decision to continue monotherapy for this length of time. I'm not ruling out an explanation that I haven't considered---there could be one in which case I'd really like to know what it was.
Avatar m tn A phase II, randomized, double-blind, placebo-controlled study of nitazoxanide treatment for 24 weeks in 50 patients with chronic HCV-4 hepatitis was performed to evaluate the safety of prolonged administration and to determine the antiviral efficacy of nitazoxanide monotherapy (46).
Avatar n tn Pegasys is not used as a monotherapy in hep C patients. If he is taking it with ribavirin that would be for hepatitis C. People with pregnant partners should not use ribavirin during their partners pregnancy. Interferon alone is sometimes used for hairy cell leukemia, kidney cancer and melanoma. It is not used for liver damage as a monotherapy since it was proven that it does not help the liver recover from damage due to any reason.
Avatar m tn 200 IU/mL, compared to only 20% in the entecavir monotherapy group (p=0.107). 24% of patients in the add-on versus 11% in the monotherapy-arm achieved HBeAg-seroconversion with HBV DNA< 200IU/ml (p=0.029). After adjustment for the difference in HBV DNA levels at week 24, add-on therapy was independently associated with higher response rates (p=0.007). In terms of other serological parameters, adding peginterferon to entecavir led to a greater decline in HBsAg (0.27 versus 0.
Avatar m tn The present study compared the efficacy of standard and extended durations of PEG-IFNα-2a monotherapy for treatment of HBeAg-negative Chinese patients with chronic hepatitis B. Patients were randomized to receive standard therapy (n = 38; 48 weeks treatment) or extended therapy (n = 42; 72 weeks treatment).
1476285 tn?1287337784 The interaction has also been reported with atazanavir/ritonavir. A case series describes three patients who experienced excessive opiate effects of buprenorphine during concomitant antiretroviral therapy with atazanavir, ritonavir, and various nucleoside reverse transcriptase inhibitors. Two of the patients had been on their antiretroviral regimen for several months and reported doped-up feeling, dizziness, and feeling high following initiation of buprenorphine 8 mg/day.
468276 tn?1207107867 It's not going to do much as a monotherapy - triple therapy YES but monotherapy NO. The following is from a very recent Clinical Care Option article. "Rossignol and colleagues reported that, although nitazoxanide monotherapy was associated with only a very modest decrease in HCV RNA (-0.
915369 tn?1355314810 It's not monotherapy, I'm on lithium and gabapentin. I've never been on antidepressant monotherapy since I was diagnosed. I'm asking about vitamin D or antidepressants because my medication now doesn't seem to do much in terms of treating the severity of my deppresive episodes, just the frequency of all my episodes, the duration, and the severity of my manic episodes.
Avatar f tn Combining peginterferon alpha-2b with entecavir for patients with chronic hepatitis B virus did not improve virological response or hepatitis B surface antigen clearance compared with monotherapy, according to study results in the Journal of Viral Hepatitis. The combination, however, did lead to greater HBV DNA suppression. “The aim of this study was to compare the efficacy of PEG-IFN monotherapy vs.
Avatar f tn Hello. Lamotrigine does have some effects on the growing fetus, but there are no conclusive reports about it being more harmful for pregnant ladies than for general population. A study conducted by Marianne Cunnington et al (NEUROLOGY 2005;64:955-960) states that,"........The risk of all major birth defects after first-trimester exposure to lamotrigine monotherapy (2.
Avatar f tn Considering the incredible adaptive power of HCV any kind of monotherapy is likely to fail. If you followed carefully what was previously presented here, one of the "official" new HCV antivirals supressed the virus by 99% after 4 days and yet after a mere 2 weeks , under ccontinuous dosing, all trial participants returned to baseline VLs- total resistance in all participants!
Avatar m tn why are they doing three days on monotherapy with each of the new drugs first? Do they think this monotherapy will improve the chances of SVR, or are they just looking for data on how big a log drop they can get from monotherapy? At least with the protease inhibitors (I believe one of these three drugs is a protease inhibitor), resistance is created during monotherapy, and none of the protocols thus far call for any monotherapy to start with.
Avatar m tn entecavir is much weaker than tenofovir especially on hbsag