atazanavir and mutation

* Boceprevir reduced average trough concentrations of ritonavir-boosted atazanavir (Reyataz), lopinavir (Kaletra), and darunavir (Prezista) by 49%, 43% and 59%, respectively. * On average, reductions of 25% to 36% were seen in peak concentration of the three drugs, when given with boceprevir, along with declines of 34% to 44% in exposure (area under the curve).

I'm a 44 year old with chronic HB and have known for for 15 years. At first I was told that I was inactive carrier, but a year ago my DNA was 100,000 IU. I am e-antigen negative and e-antibdy positive. My liver functions are normal. I was told that I have a pre-core mutant. What does that mean and should I do? Please help.

A case series describes three patients who experienced excessive opiate effects of buprenorphine during concomitant antiretroviral therapy with atazanavir, ritonavir, and various nucleoside reverse transcriptase inhibitors. Two of the patients had been on their antiretroviral regimen for several months and reported doped-up feeling, dizziness, and feeling high following initiation of buprenorphine 8 mg/day. The dosage was reduced to 8 mg every other day.

Mutations are when the cirus integrate into the dna and makw enhancements to it. It is beleived that precore mutation and basal core promotor increase the risk of hcc for hbv carrier.

What is the risk of double pc mutation at g1896a and c1858t combined with bcp mutation at a1762T and G1764A with Genotype C. It seems I am really @#$$@#$ . Will these 2 combinations create antiviral resistance?

MTHFR - (Methylene-tetra-hydro-folate-reductase) is an enzyme found in the cells of our body. It is needed to metabolize (break down) homocysteine, an amino acid found in the proteins you eat. Elevated homocysteine levels have been associated with fetal neural tube defects (i.e., spinal Bifida) and miscarriage. An elevated homocysteine level can also indicate a increased risk factor for blood clots, arteriosclerosis (hardening of arteries) and strokes in both men and women.

The presence of the A1298C mutation in the MTHFR gene in conjunction with C677T, has been associated with decreased MTHFR activity and hyperhomocysteinemia. The frequency of the A1298C mutation is reported to be as high as 30% in the general Caucasian population. Presence of the A1298C mutation alone does not result in hyperhomocysteinemia. MTHFR mutations, when present with other genetic thrombophilic factors dramatically increase risk for venous thrombosis. Prof.

html A1762T/G1764A and G1899A this is my situation....

I have a double copy of mthfr gene mutation... A1 & C6....

I am 13 weeks pregnant and I have had two miscarriages and 1 live birth, my son. With my son I had PreEclampsia so the new OB that I am going to did a test MTHFR and it came up with two blood mutations C677T and A1298C which he says together could lead to a miscarriage or Pre Eclampsia but treated my risks are reduced. So I am starting a shot each day of Lovenox and a baby asprin along with my prenatals and iron.

Jimeeboy, There's a test, think it's called GenoSure, that can be done to determine what resistance and genetic mutation you had in response to Telaprevir (or Boceprevir). Btw, read your comments the other day and am wondering what you're thinking now about screening for the BMS/7977 trial? Good luck with everything!

And let met add, the methylfolate form is also synthetic. The form found in food is folate.

We recommend that you meet with a genetic counselor who can review your personal and family history as well as discuss the genetics and inheritance of MTHFR deficiency. You can find a genetic counselor at the National Society of Genetic Counselors website or through companies like mine, AccessDNA. We wish you the best.

I think too when it is a situation like this, finding someone that is a national expert in it and consulting with them even if over phone or video call or email is a great idea. What's happened since you wrote this?

He had his HBIG before 6 months, but now with a viral load going up, living in the same house hold and having genotype c double mutation, I worry for him. I hate to have him have these issues that I am going through.

In this particular article it talks about the S282 mutation. I believe this was the mutation that they were concerned about, as far as resistence. I hope it is anyway because as you can see in this trial it says, NO PATIENT DEVELOPED S282 mutation. When you talk to your doctor this week, maybe you can ask him about the resistance factor (I'm sure you already plan on it). http://www.gastroendonews.com/ViewArticle.aspx?

Today I was brainstorming with a friend about meds for this and headaches and she asked me about the MTFHR gene mutation. I have had the test in the past and it showed that I have the double gene mutation. In doing research, I found medical studies showing a direct link to the homocysteine levels and the GFR levels for the kidneys. As this is not a normal blood test, it was not tested for while I was in the hospital.

Today I was brainstorming with a friend about meds for this and headaches and she asked me about the MTFHR gene mutation. I have had the test in the past and it showed that I have the double gene mutation. In doing research, I found medical studies showing a direct link to the homocysteine levels and the GFR levels for the kidneys. As this is not a normal blood test, it was not tested for while I was in the hospital.

Also it is rare to have ovarian cancer in both ovaries. It happens but it is rare. I had both ovaries but I have the BRCA mutation and I had cancer in 14 places. They could see the cancer on the ultrasound. Over 98% of ovarian cysts are benign. What does your doctor say. You could have Polycystic Ovary syndrome which is not cancerous.

I am still waiting on the results of the blood test for me. They are doing a cgh test on my son and it showed chromosone 5 and they are fishing with my dna and his. He also seems to be having Jacksonian seizures. Is this a possibility? Thank you again for your help.

Atazanavir and mutation

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