Arimidex and bone loss

Common Questions and Answers about Arimidex and bone loss

arimidex

My bone density is deteriorating, thus I would like to know whether I have to take osteobond 70mg weekly. Will arimidex contribute to loss of bone density? Thank you very much. Susan. This discussion is related to <a href='/posts/show/261175'>arimedex</a>.
I recently had a mastectomy and then the surgeon sent me to his colleague, an oncologist. I told him I did not want to take Tam- oxifan and he gave me a prescription for Arimidex. I've been taking it for 2-3 weeks and have had no side effects at all, except for a few hot flashes, which don't bother me.
Judging by the number and speed of replies to the first post, I would venture to say joint, bone and muscle pain is not so uncommon a side effect of Arimidex. I began the drug about 3 months ago after 4 cycles of CT and I can attest to the onset of stiffness and pain in my hands, fingers, knees and hips already. This is certainly worse in the morning but even in mid day after sitting for 20-30 minutes standing up to walk again requires slow and cautious moves.
Is there something else she can take to increase her bone density besides the commonly used drugs now marketed for increasing bone density? I am at a loss because the Arimidex can cause further bone loss, but without it she would be without benefit of an estrogen blocker. Help!
* Back pain** * Cough * Difficulty breathing** * Osteoporosis [ I already have it]** * Accidental injury * Broken bones** * Insomnia (see Arimidex and Insomnia) * Swelling or water retention in the arms or legs [Lymphedema type]** * Abdominal pain (stomach pain) * Constipation * Diarrhea * High cholesterol (see Arimidex and High Cholesterol) * Infections * Weight gain (see Arimidex and Weight Gain) * Breast pain * Dizziness** *
Is there something else she can take to increase her bone density besides the commonly used drugs now marketed for increasing bone density? I am at a loss because the Arimidex can cause further bone loss, but without it she would be without benefit of an estrogen blocker. Help!
I have been on Arimidex for 4 yrs. A recent DEXA scan showed significant bone loss since starting Arimidex, compared to the one done prior to commencing Arimidex. I have Crohn's and had steroids for 30+ yrs, so that DEXA was ordered by my gastro. I am now on weekly self injected methotrexate which is doing a great job in keeping the Crohn's in remission. I have osteopenia, osteo-arthritis in both hips, hands and feet, and had 2 spontaneous fractures in either feet last summer.
but, my bc surgeon took my hip pain seriously and ordered the bone scan, and a DEXA scan, which showed much thinning of my bones. I have had to accept some of the problems of the ageing process. I am intrigued as to why you came off Arimidex for 6 months....why? I am coming up to 5 yrs post dx and am wondering how I can protect myself from a recurrence of bc if my bc surgeon takes me off Arimidex. take care, Liz.
Are there any reports on weight gain, vaginal discharge, hair loss, hot flashes and sore legs and feet? (I have all of those symptoms - and I blame them on Tamoxifen - and I feel it's affecting my quality of life). I have been on Tamoxifen since April 2001. Thanks.
I have had increasing debilitating severe pain in left hip, left foot and both hands. DEXA scan showed increased bone density loss to that of a DEXA scan done before bc (ordered by gastro due to 30+ yrs of steroids). BC surgeon prescribed Fosamax and Calcichew/Vit.D3. A bone scan showed osteo arthritis in both hips, hands and feet. No meds prescribed. I am on weekly injections of 12.5 mg methotrexate for Crohn's.
What I wold also like to know is, do I need to be on Arimidex after the oopherectomy, isnt that enough to stop the Estrodial?. I now take Fosavance once a week to try and rebuild and maintain my bones and wonder if this is a waste of time as the Arimidex causes the osteopenia, so if I stay on that am I going to continue losing bone density? The Fosavance has its own abundance of side effects that are pretty scary.
What are the side effects of not having ovaries and how bad is it? I heard sexual desire lowers which concerns me, bone loss and heart desease. I am only 45. Also she is considering switching me to Arimidex if I have surgery. Is it better tohave 5 years of Tamoxifen and 5 years of Arimidex being I'm so young? When I ask the doctors what caused the cysts, they say they don't know.
A plain x-ray of the hip only shows advanced bone loss if there are cancer metastases. A bone scan may be a more sensitive test, but may not detect bone metastases if there is not sufficient bone inflammation yet. An alkaline phosphatase test is a non-specific enzyme that would likely be elevated if there was significant bone damage. Certainly, joint pain is one of the documented side effects of Arimidex. However it can also be an early sign of bone metastases.
I have osteopenia and osteo-arthritis, and bone density loss. Mine is caued by 30+ yrs of steroids and for 4 yrs, the breast cancer drug Arimidex, which does not protect the bones as tamoxifen does. My bc surgeon prescribed a bisphopshonate, Alendronic Acid (think it is called Zometa in the US) which I take once weekly, and Calcichew/Vit.D which I take twice daily. Both are to build up my bones and prevent further loss.
It is of course her decision re whether lowering the risk in her case is worth enduring the side effects. If she does choose to take an AI and the side effects of Arimidex are intolerable, she could see if she would do better on a different one. However, in at least one recent study, Arimidex came out ahead of the others in preventing recurrence. Best wishes to both you and your wife...
two years ago and, and in FEb of 2006, I finished 9 cycles of Gemzar and carboplatin. Disease appears stable now but CA 125 has risen slightly. I expect to be in treatment soon within a few months. MDs just started me on Airmidex. Any info about any success with Arimidex would be appreciated as well as any infor on bothersome side effects and do these side effects lessen? I was already on Tamxoxifen sevral years ago after treatment for breast cancer and recall the hot flashes.... Thanks!
Hi there - I have IDC breast cancer and Crohn's and have had monthly B12 shots for some 25 yrs. Luckily, I didn't lose my hair when on FEC chemo for breast cancer,as I had the cold cap treatment alongside, but it thinned enough that I could see my scalp on top of my head. 30+ yrs of steroids has thinned my bones significantly, so I was prescribed a bisphosphonate (Alendronate) alongside calcium (Calcichew) and Vitamin D3. My hair is a lot thicker now. You might wish to get tested for Vit.
Denosumab has shown promising results in the management of bone metastases, bone loss due to cancer treatment, and postmenopausal osteoporosis. Denosumab in Men Receiving Hormonal Therapy for Non-metastatic Prostate Cancer Clinical studies have consistently shown that men experience a rapid loss of BMD within the first six to 12 months of androgen deprivation therapy (ADT). The HALT Study involved 1,468 men undergoing ADT for non-metastatic prostate cancer.
What are the benefits and risks of taking arimidex as adjuvant treatment for ER+ breast cancer tumors?
I do get a lot of bone and joint pain from the meds I am taking (arimidex) but I need to lose this weight and try to get back as close to my "pre-cancer" body as I can. I am very upset about all these changes. I know that my priority is survival but it still does not change the fact that I am upset about this new look of added weight. What can you suggest for someone who is in menopause to help with the weight loss?
) I'm not sure why certain doctors still deny hair loss as a possible side effect of chemo and the AIs (as well as other side effects like severe bone and/or joint pain, etc.) but that's why a community forum such as this is so valuable--information about various txs is shared among women "who have been there," not just doctors who write prescriptions... I don't have any practical ideas to help you; just want to know my heart aches for you.
I could only sleep 2 hours before being woken up by the pain in my left hip - bone scan and DEXa scan showed osteo arthritis and bone density loss, but don't believe they could cause such debilitating pain...and I have been proved right. What took me so long? absolute naivety and ignorance of the side effects...why don't our doctors tell us about these? Are you on any kind of hormonal therapy? These could be the culprit.
Bone mass is greatest in women's 20s and 30s; it stabilizes between 30 and 40, and over 40 there is slow loss of bone strength. After menopause, there is a five- to seven-year period of accelerated bone loss; then the rate slows and returns to an age-related rate. The aging process has a greater effect on bone loss than the presence or absence of estrogen.
UNTIL I started taking Arimidex almost three years ago. NO one told me about the hair loss...and this time it is permanent and distressing. I could take losing my hair from chemo, knowing that it would return. However this is different. My brush is always full of a clump of hair. You can imagine that after three years...my hair is very thin. The pattern of loss is greatest from ear to ear; just where you need your hair the most.
Now in september it is 75 and the doc wants another whole work up. I did have bone scan and chest xray which were negative. He put me on arimidex in Dec 2001. I don't want to stick my head in sand here but am refusing further testing at this time because I am having knee replacements next week. I went for another opinion and the thot was why arimidex when no evidence of disease. Also felt the marker should have been repeated before anothe million dollar work up.
With being on steroids for Crohn's some 30+ years, and now on Arimidex for breast cancer, my bone density has been seriously depleted. Because my bc had spread to my lymph nodes he wants me to stay on Arimidex, but he, and I , know it does not protect the bones like tamoxifen does, but has a better survival from recurrence. A catch 22 he told me. I have been taking alendronic acid (bisphosphonate) for a year now, with Calchichew/Vit D, but my bone density is getting less.
They are prescribing Fosomax to help prevent bone loss. She may talk to her onc and see what they think. Ihope this helps!!
As you have implied, however, aromatase inhibitors can have side effects such as joint aches and pains as well as bone density loss. It should be noted that the anti-osteoporosis drug Evista is chemically similar to tamoxifen and it is not recommended that either tamoxifen or Evista be used in combination with an aromatase inhibitor as they may interfere with its activity. This is not true for bisphosphonates such as Actonel, which appear to be safe in this setting.
only in the last 2 or 3 yrs (I am a young 63 yrs!) have I had serious problems with osteo-arthritis and serious bone density loss. My fingers are quite deformed and hurt badly.My left hip also stops me from sleeping properly. I had two spontaneous fractures in both feet last summer - spent a month in a wheelchair and another month on crutches.
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