In the early breast can
cer clinical trial, the most common side effects seen with ARIMIDEX include hot flashes, joint symptoms (including arthritis and
arthralgia), weakness, mood changes, pain, back pain, sore throat, nausea and
vomiting, rash, depression, high blood pressure, osteoporosis, fractures, swelling of arms/legs, insomnia, and headache.
Patients taking ARIMIDEX were less likely than those taking tamoxifen to stop treatment because
of side effects.