There is a newer class of drugs referred to as DMARD's. One of these is Arava
. This is very expensive though even in it's generic form ($400-500 a month), so it depends on your insurance whether this will work for you. I have not noticed a ton of relief from joint pain yet (6 weeks so far), but I do have more energy, and less fevers. There are many new drugs in this category, but I'm not familiar with many of them yet. Give the Plaquenil a fair run.