Although we do not yet have data on the safety, for ER+ BC survivors, of the use of locally (vaginally) applied
estrogen products, two, Vagifem and Estring, provide very low doses of estrogen. Estring, for example, releases over 90 days an amount equivalent to taking oral estrogen for just 2 days, and Vagifem, aready a very low dose estrogen product, is now available in a 10 mcg dose, as well as the original 20 mcg dose.