Anastrozole vs tamoxifen
Common Questions and Answers about Anastrozole vs tamoxifen
arimidex
Dr. Goodman- my Ca125 appears to be rising & my doctor has put me on tamoxifen. I know this is used in breast cancer pts but what is it used for in ovca pts? My recent PET/CT scan did not show any recurrent disease.
, locoregional or distant recurrence or contralateral breast cancer), postmenopausal women with hormone receptor–positive breast cancer should consider an AI, either as primary adjuvant therapy for 5 years or sequentially after 2 to 3 years of tamoxifen to yield a total of 5 years of adjuvant endocrine therapy. Women who discontinue initial AI therapy before 5 years should consider using tamoxifen to bring the total duration of adjuvant therapy to 5 years.
Dear river1980, Both Femara (letrozole) and Arimidex (anastrozole) are aromatase inhibitors used in the treatment of hormone receptor positive breast cancer in post menopausal women. Aromatase inhibitors block the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
Thanks for any feedback,
Laurie .
I was diagnosed with T2N0M0 breast cancer and went for mastectomy followed by 4 sessions of Taxotere. Now my doctor prescribed Aromasin alone for 5 years. He did not give me Tamoxifen first followed by Aromasin, but just Aromasin for 5 years. Is this acceptable ? I am 57 years old, mother of 4 children.
Please advise.
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
Hi. How old are you? Are you post-menopausal? Exemestane (Aromasin) and similar drugs called aromatase inhibitors, will only work with women who have already undergone menopause. If you're in the reproductive age group, Tamoxifen is still your primary option for hormonal treatment.
Perimenopausal breast cancer survivor on tamoxifen. After 4 months, diagnosed with AUB due to simple hyperplasia and polyps. Given a choice of hystrectomy or Ablation. Can't find any literature regarding ablation followup care since tamoxifen would be continued for 2-3 more years. What is the risk of endometrial carcinoma or other gyn issues after ablation since tamoxifen would still be providing an estrongenic effect?
Now endo is suggesting that in order to give him more time to grow, we give him Anastrozole. I have seen lot of posts and spent hours on the forums wherever I found mention of advanced bone age/Anastrozole/Letrozole. It seems there are quite a few posts under Pediatric Endo forum but not able to find any answers if any parents tried Anastrozole/Letrozole and what has been their experience regarding delaying bone age and side effects.
Have developed a heart rhythm disturbance, shortness of breath, edema of hands and legs/feet since being on Anastrozole. How worried should I be? Should I consider discontinuation discussions with my Dr.?
This discussion is related to <a href='/posts/show/542261'>Can Arimidex Cause Skin Lesions?</a>.
I have been on Anastrozole for year, 4 more to go (5 ys.) I have the worse Joint pain, stiffness, hurts to walk, get up from chair, I get out of bed hurting, I ache everyday. My skin and stays so dry, my hair grew back after chemo, but is lifeless, thin, etc. I do not like this Pill and want to discontinue, but my Oncologist said it is doing me more good, to keep taking it. This pill is really aging me, dry wrinkly skin, no energy, cant walk and move like I want to.
It does act as an anti-estrogen but also acts like estrogen in that it prevents the bone loss that other drugs like Tamoxifen may cause. It actually has the same side effects as Tamoxifen but not every person will experience all of these side effects or to the same degree. I'm not sure what you mean by "it made me ill" ... you may have the same side effects with the other drug but it's worth a try. Regards ....
Hi,
I can't seem to find stats anywhere on the Web for Stage I Breast Cancer, if you've had BCS but no radiation. Even stats for Tamoxifen,eg, all seem to assume you've had radiation. I had a lumpectomy; lymph nodes are clear, the tumour is only 1.1 cm, invasive tubular, as well as DCIS and one focal point of LCIS.
Hi. I'm on tamoxifen so I can't take any meds which inhibit cyp2D6 enzymes. I've been on almost ALL SSRI ( Effexor, lexapro, celexa, nortriptyline, fetzima, & viibryd) & my depression worsens with them (suicidal thoughts, etc). The only one that has helped is remeron but every time I've had to return to remeron I gain weight. I'm usually 110-112 and eat very well & workout almost everyday.
Herceptin and Tamoxifen are different drugs with entirely different actions. One does not replace the other in treatment. Tamoxifen blocks Estrogen and Herceptin deals with the over production of a protein. They are often given together. As the previous poster stated; if your tumor was Her2 positive you should definitely follow the Herceptin recommendation. Regards ...
I was recently diagnosed with DCIS, ER/PR negative and, because of extremely dense breasts, chose to have a bilateral mastectomy. I'm glad I did, because a 5mm invasive tumor was found. The tumor was Grade 1, ER/PR postive, Her-2 negative. My oncologist recommended doing nothing or, if I wanted to have some treatment, receommended tamoxifen. I've heard that Tamoxifen doesn't kill microscopic cancer cells elsewhere in the body but only inhibits their growth...
Just to add to what Lauren said regarding tamoxifen vs. other AI's, they do work differently in the body. Tamoxifen works by blocking the body's use of estrogen, whereas AI's reduce the amount of estrogen present in the body. In studies of breast cancer patients, AI's have proven to work better than tamoxifen in preventing recurrence, and there are far fewer serious side effects with AI's than with tamoxifen, too. Tamoxifen can cause blood clots, and stroke..
As of right now we are holding off on meds. He is growing but still just a little each year. He hasn’t hit a growth spurt yet but I’m hoping he does very soon. My son is 4’6” now and I worry so much that he is not going to reach anywhere near his mid parental height. How tall is your son? We have seen an endocrinologist who thinks anastrazole would be a good way for him to get closer to his potential, but I am so scared to put him onedicines just to gain a few inches.
Hello,
I'm writing on behalf of my wife, she is 42 years old, premenopausal, and being treated (radiation therapy to come) for invasive ductal carcinoma, without any evidence of spread to nearby lymph nodes or distant sites, 1/0,8 mm tumor, low/moderate grade tumor, er+, pgr+, no family history of breast/ovarian cancer.
Although our oncologist generally treats young women more aggressively, my wife's tumor is so small he has recommended just radiotherapy.
im on anastrozole.
I just saw a film Cut Poison Burn that pretty much said what the lady's dr in Puerto Rico advised: not only does the use of tamoxifen double the patient's chances of uterine cancer but taking it more than five years also increases the chances of breast cancer.
Why would you advise a lady who does not have cancer to take a drug that causes cancer?
The oncologist switched me to Anastrozole but the Anastrozole failed. My mom passed away at the age of 97 from omentum cancer. We didn't know she had cancer until 2 months before she passed. It's a very slow growing cancer. We had no idea and had never heard of omentum cancer before but we were later told It's a metastasis from the ovaries. My recent telehealth appointment with Sloan-Kettering the oncologist suggested exemestane Hormone blocker. Wishing your mom the best.
If you've had Hashimoto's for that long, have you also been on any replacement thyroid hormone medication? If so, what medication, dosage and for how long?
Have you had Free T4 and Free T3 tested to determine actual thyroid hormone levels? If so, what are their results, with reference ranges?
I've read that there's a connection between breast cancer and thyroid disease, but I'm not exactly sure what it is.
The test also said that people with scores of 31 or higher had a 40% chance of recurrence with Tamoxifen alone, and 12% with Tamoxifen and CMF/MF. My oncologist said that the chemo drugs used in this study are old, and the outcome could even be 30% better with the new drug combos. Are there studies like this using my score and the new chemo drugs?
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