Anastrozole bioequivalence
Common Questions and Answers about Anastrozole bioequivalence
arimidex
Now endo is suggesting that in order to give him more time to grow, we give him Anastrozole. I have seen lot of posts and spent hours on the forums wherever I found mention of advanced bone age/Anastrozole/Letrozole. It seems there are quite a few posts under Pediatric Endo forum but not able to find any answers if any parents tried Anastrozole/Letrozole and what has been their experience regarding delaying bone age and side effects.
Have developed a heart rhythm disturbance, shortness of breath, edema of hands and legs/feet since being on Anastrozole. How worried should I be? Should I consider discontinuation discussions with my Dr.?
This discussion is related to <a href='/posts/show/542261'>Can Arimidex Cause Skin Lesions?</a>.
I have been on Anastrozole for year, 4 more to go (5 ys.) I have the worse Joint pain, stiffness, hurts to walk, get up from chair, I get out of bed hurting, I ache everyday. My skin and stays so dry, my hair grew back after chemo, but is lifeless, thin, etc. I do not like this Pill and want to discontinue, but my Oncologist said it is doing me more good, to keep taking it. This pill is really aging me, dry wrinkly skin, no energy, cant walk and move like I want to.
im on anastrozole.
The oncologist switched me to Anastrozole but the Anastrozole failed. My mom passed away at the age of 97 from omentum cancer. We didn't know she had cancer until 2 months before she passed. It's a very slow growing cancer. We had no idea and had never heard of omentum cancer before but we were later told It's a metastasis from the ovaries. My recent telehealth appointment with Sloan-Kettering the oncologist suggested exemestane Hormone blocker. Wishing your mom the best.
If you've had Hashimoto's for that long, have you also been on any replacement thyroid hormone medication? If so, what medication, dosage and for how long?
Have you had Free T4 and Free T3 tested to determine actual thyroid hormone levels? If so, what are their results, with reference ranges?
I've read that there's a connection between breast cancer and thyroid disease, but I'm not exactly sure what it is.
As of right now we are holding off on meds. He is growing but still just a little each year. He hasn’t hit a growth spurt yet but I’m hoping he does very soon. My son is 4’6” now and I worry so much that he is not going to reach anywhere near his mid parental height. How tall is your son? We have seen an endocrinologist who thinks anastrazole would be a good way for him to get closer to his potential, but I am so scared to put him onedicines just to gain a few inches.
My son is on GH for GHD. Also did 2.25 yrs anastrozole since bone age was slightly ahead. Now only on GH. Age 15.5, bone age 13.5-14. Has all the puberty markers for tanner 4: pubic hair now starting a line to navel. Has to shave a couple times per week but only few hairs in beard area, voice deeper but no prominent adams apple yet. A year ago at endo appt we were told he didnt have to endure anymore testicle size checks. I assume that means they are near adult in size.
Dear river1980, Both Femara (letrozole) and Arimidex (anastrozole) are aromatase inhibitors used in the treatment of hormone receptor positive breast cancer in post menopausal women. Aromatase inhibitors block the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
Thanks for any feedback,
Laurie .
i. symptoms be a side effect of anastrozole (arimidex)? I have been taking it for 3 1/2 years, after 1 year on tamoxifen, following lumpectomy, chemo and radiation.
Hi there,
Thank you for answering my question. No,she is not on chemo therapy,she's on Faslodex250 mg.shots,Anastrozole 1 mg,and medicine from the doctor for itching and dry skin, plus a cream or lotion they put on her alot. I compared medication she was on before this itching started and
what she's on currently.....not much difference,just more pain meds,asprin,
and breast cancer medicine.
I have been taking Anastrozole for about two and half years for stage 1 ER/PR positive breast cancer. About a year after I started taking the drug, I was diagnosed with Type 2 diabetes that is not particularly well controlled, even though I take two different prescriptions. A few months after that I was diagnosed with high cholesterol. For that I now take Lipitor, which has lowered the total cholesterol quite a bit.
The fine print about the bioequivalence, shown at the bottom of this letter, is all we know about the comparison between the old and new formulations.
5. They received a call yesterday from someone asking if aspartame had been added to the new formula.
6. Pfizer thanked me for my "concerns" (God, how I hate that word), and they got an earful from me about their failure to communicate effectively with their customers.
Mark Yannone
SplendaSickness.blogspot.com
AspartameSickness.
Regarding ribavirin I agree with others; there should be letters of bioequivalence available from various manufacturers and again, no clinical difference in product efficacy.
I am 63 and just diagnosed with Stage 1, ER/PR Positive, node negative invasive ductal carcinoma. My oncologist is in the process of deciding whether to prescribe Letrozole/Femara or Anastrozole/Arimidex. What considerations factor into which of these two drugs to use? Has anyone had experience with either of them? How serious are the side effects?
There are a lot more factors that go into generics vs. brands (like its pharmacokinetic profile and bioequivalence (BE) and bioavailability (BA).....but it's a tad more complicated than is appropriate for this forum)
There has been a VERY long lived debate about the efficacy of generic vs brand name meds. For most people, they seem to be able to use either interchangeably with little or no difference in the effectiveness.
If her cancer is hormone responsive (you can ask her doctor to verify this), she may benefit from taking hormonal treatment like anastrozole, letrozole, or fulvestrant, instead of receiving chemotherapy.
Today the results of the Oncotype DX was 8 and the doctor gave me Arimidex (anastrozole) 1mg tablets and I am scheduled to see the radiologist next week. I think with all the side effects of the medicine, it sure is scary, but I will try it. If it gets me sick or if I am unable to take it, then I won't take anything. I also want to see what the radiologist suggests as far as how many tx's I will need to take. I guess time will tell.
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