I am very overweight with a bmi of 41, male, 33 years old, and a smoker (trying to quit). I was put on metoprolol200 mg per day,
amlodipine 10 mg, and since my high sensitivity c-reactive protein was 8.9, I was put on simvastatin 5mg. The medicine was controlling my blood pressure over the last couple of months but now it is not. I consistently run in the 150/95 range. My resting heart rate stays around 90. Is it normal for meds to just stop working, literally overnight?