No, you're in no danger with that low a dose of Ambien and a glass or 2 of wine. Actually, it's like 2 glasses instead of 1, or 4 instead of 2. I wouldn't go too far, though, because in LARGE Doses, it could be dangerous, even fatal By Large, I mean like 6 pills and 6 glasses of wine. So, whatever works for you. Consider tolerance, body weight, etc.