Hello~Certain drugs will say not to, but if they don't, or if they are vitamins, herbs or minerals, I don't see any reason not to. I use to do it with all my vitamins due to food allergies, you see, most of the capsules are made from beef gelatin, I was allergic to beef, so I opened them up and put the contents in orange juice, it didn't taste too great, but it was the way for me to get my vitamins.