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Avatar n tn Updated A Study of TMC435 in Combination With Peginterferon Alfa-2A and Ribavirin for Hepatitis C Virus Genotype-1 Infected Patients Who Participated in a Control Group of a TMC435 Study Jackson : G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS Updated Evaluating Three Grams Daily Valacyclovir in Patients With Chronic Hepatitis C and HSV-2 Infection (Phase I) Jackson : G.V.
Avatar f tn 1 ratio to one of two INCIVEK combination treatment groups (with and without a Peg-IFN-alfa-2a/RBV lead-in) or a control group. The T12/PR48 group received INCIVEK and Peg-IFN-alfa-2a/RBV for 12 weeks (without a lead-in), followed by placebo and Peg-IFN-alfa-2a/RBV for 4 weeks, followed by Peg-IFN-alfa-2a/RBV for 32 weeks.
Avatar m tn A small trial failed to demonstrate that interferon alfa-2b prevented cirrhosis in HBeAg-positive patients. Another small RCT found no significant difference in histologically confirmed cirrhosis after interferon alfa-2b alone or with simultaneous prednisone. No data were available from RCTs for other antiviral drugs or longer followup. Hepatic decompensation was not prevented by lamivudine compared to placebo or entecavir compared to lamivudine in three underpowered trials.
137025 tn?1217764741 Willow, did you treat with Telaprevir in the early trials? Or are you waiting to try it still? For some reason, (maybe I have you mixed up with somebody else), I thought that you were in the trial before. I was in Prove 3 Group C, the no Riba group and I didn't clear it by week 4. But, I don't consider myself a non-responder. I consider myself a partial responder because I had a huge drop in my viral load in week 1-2. I just rebounded because of not have the Riba in the mix.
Avatar m tn Results -- More patients in group A than group B achieved an SVR (110/160 [68.8%] vs 87/160 [54.4%]; P = .008). Higher SVR rates were obtained in group A than group B among patients with genotype 1/4 (51/93 [54.8%] vs 37/93 [39.8%]; P = .04), with genotype 2/3 (59/67 [88.1%] vs 50/67 [74.6%]; P = .046), without cirrhosis (96/127 [75.6%] vs 75/134 [55.9%]; P = .005), and with baseline levels HCV RNA >500,000 IU/mL (58/84 [69%] vs 43/93 [46.2%]; P = .002).
148588 tn?1465778809 12 weeks of telaprevir plus peginterferon alfa-2a/ribavirin followed by another 12 weeks of peginterferon alfa-2a/ribavirin (T12/PR24); 24 weeks of telaprevir plus peginterferon alfa-2a/ribavirin followed by an additional 24 weeks of peginterferon alfa-2a/ribavirin (T24/PR48); 24 weeks of telaprevir plus peginterferon alfa-2a and no ribavirin (T24/P24); or 48 weeks of peginterferon alfa-2a/ribavirin (the control arm) (PR48).
Avatar f tn MRK), known as MSD outside of the United States and Canada, reported that final results from a Phase III study of VICTRELIS™ (boceprevir), its investigational oral hepatitis C protease inhibitor, added to peginterferon alfa-2a (Pegasys®) and ribavirin therapy demonstrated significantly higher sustained virologic response (SVR)1 rates in adult patients who failed previous treatment for chronic hepatitis C virus (HCV) genotype 1 compared to a control group receiving peginterferon alfa-2a and riba
980756 tn?1313445908 The PIs will up your chances of cure, and may allow you to treat for half the time. The only obstacle is the insurance issue, since no one really knows yet how it will go down. Good luck whatever you decide.
2030686 tn?1351688548 Ocular side effects associated with oral ribavirin in combination with peginterferon alfa-2a, peginterferon alfa-2b, or interferon alfa-2b have included blurred vision (up to 6%). Corneal ulcer has been reported in less than 1% of patients treated with peginterferon alfa-2a alone or in combination with ribavirin tablets. Conjunctivitis (up to 5%) has been reported with ribavirin capsules/oral solution in combination with peginterferon alfa-2b or interferon alfa-2b.
1628149 tn?1299785675 Hi there; welcome to the discussion group. Have you considered participation in clinical trial? Do you need to treat soon, or can you wait? If you reside in the U.S. you can call the manufacturers of the HCV drugs to see if you’ll qualify for patient assistance; they often provide the drugs free of charge for those that are uninsured. However, they don’t cover doctor’s care, labs, procedure costs, etc.
303646 tn?1214947727 m supposed to have my 12 wk PCR done next Thursday but I asked the doc to hold off until July 1st because my group insurance kicks in and pays a whole lot better than private pay. My numbers have been skewed from the beginning so I don't feel like it will make a huge difference whether I have 12 wk PCR done in two weeks. If everything had gone like it was supposed to I would be very anxious to know because UND at 12 wks gives you a better chance of SVR.
4097344 tn?1349754756 im in need of some help. i need health insurance but i just lost my job. now that i have palpitations im scared to drive or do anything. i went to the er and they did a ct scan with contrast and said they didnt find anything wrong. i just feel like crap. out of energy. all blood test came back good. i got a ct scan with contrast for my head last week but i havent heard back from them with the results so im guessing they didnt find anything.
Avatar m tn Ocular side effects associated with oral ribavirin in combination with peginterferon alfa-2a, peginterferon alfa-2b, or interferon alfa-2b have included blurred vision (up to 6%). Corneal ulcer has been reported in less than 1% of patients treated with peginterferon alfa-2a alone or in combination with ribavirin tablets. Conjunctivitis (up to 5%) has been reported with ribavirin capsules/oral solution in combination with peginterferon alfa-2b or interferon alfa-2b.
1391695 tn?1298139789 Not necessarily, Bree. Well, actually you might be covered, but to what extent is often the case. Some insurance policies cover the riba under their Rx plan but put the IFN into major medical, sometimes requiring 30% copay. That happened to me, and while I paid the first time out of pocket, the second treatment I went through the mfgr’s patient assistance program; they paid for 100% of both meds, with no copay or deductible to meet.
Avatar m tn These include albinterferon, controlled-release recombinant interferon alfa, maxy-alfa interferon, oral interferon, and implantable mini-pump technology to deliver continuous interferon infusion. Albinterferon* was developed by genetically fusing human albumin to interferon alfa. The concept is that this recombinant agent will have a longer sustainable half-life and thus allow a reduction in the frequency of interferon administration.
Avatar m tn The investigators found a primary endpoint was reached by 17.8% (51/286) of patients in the peginterferon alfa-2b group versus 20.4% (55/269) in the colchicine group in the ITT analysis, and by 12.2% (35/286) and 16.0% (43/269) patients, respectively, in the on-drug analysis (treatment differences were not statistically significant). Among patients who had portal hypertension (42.3% and 48.
Avatar n tn 48,52-54 In a preliminary study, 21 patients with chronic HCV genotype 1 infection in whom treatment with peginterferon alfa and ribavirin had failed were randomly assigned to receive 60 mg of daclatasvir (an NS5A replication complex inhibitor) once daily and 600 mg of asunaprevir (an NS3 protease inhibitor) twice daily, either alone (group A) or combined with peginterferon alfa and ribavirin (group B) for 24 weeks.
Avatar f tn I have been doing a lot of research on health insurane lately, since I am switching from a student (group) health insurance plan to a private (group) plan. One thing I found out, is that all of your medical records are an open book to any medical insurance company. If you have a pre-existing condition such as a back injury, cancer, or other, go with the group medical insurnace, it is regulated so that they have to accept any illness no matter what the pre-existing condition is.
Avatar n tn Pegasys is a brand name for Peginterferon alfa-2a or Pegylated interferon alfa-2a which is an antiviral drug made by La Roche. It is given by injection. It is used in combination with another medication called Ribavirin (a pill), and a third medication, either Victrellis or Incivek, which are both pills, to treat Hepatitis C. Let us know if you have further questions.
Avatar f tn Hey guys, I can only say that i everyone is feeling well but i know how it goes, seems the odds are against me my insurance company can't come to an agreement. Any suggestions? I have been tryin to get treatment since my biopsy , over 5 months age God I need help my doc keeps tryin with no success:(:( I feel as if i am being denied medical attention you know? Can anyone tell me how to move this process along ? Like i said it has been 5 months waiting.
1532707 tn?1312155924 I have BCBS group plan but not any vision and I was thinking about going to the opthamologist to see about my eye cause they feel dry alot of the time despite artificial tears. The other day I was just sitting on the couch and I saw stars. My MS started with optic neuritis but I thought it was a migraine and I never went to the doctor for it. Is it covered? I think its not nescessarily vision but it does pertain to the eyes. Whats your experience?
476246 tn?1418870914 We observed no between-group differences in viral load reduction over time and no differences in the percentage of patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin who achieved early virologic response (EVR), defined as >/=2-log reduction in HCV RNA concentration or undetectable HCV RNA at 12 weeks (66%vs 63%).