Actos and heart attack

Common Questions and Answers about Actos and heart attack

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I am a diabetic who had a mild heart attack in Nov., 05. At that time, my symptom was a tingling sensation on each side of my sternum - both at rest but especially with exertion. Still, once at the ER, I was surprised to learn I'd had a mild heart attack. I had two drug-eluting stents placed in clogged arteries. SInce then, I've been taking several medications for heart and diabetes, including Plavix, aspirin and now Actos for the diabetes.
I got very anxious about the weight loss and thought I had cancer and then went to the pharmacy and started research and found out it was the met that was doing it. One morning I woke up and had shed 4 lbs overnight. I generally have very little appetite - use to lick my plate and now I don't finish even the smallest meal. I do seem to crave sweets late in the evening. (Maybe I SHOULD take it in the evening!
Metformin short circuits to some degree insulin's negative role. Metformin also reduces lipids (cholesterol) and so has very positive effects to preventing heart disease and reducing blood pressure. Google any of these terms in relation to Metformin and you will see. If you are a person who has tried to lose weight though calorie control and exercise, but have failed, you should try Metformin.
It is sad when people treat and don't make it. For the people who treat and for everyone else watching. It is heart breaking and that why people want to give good advice.
ToprolXL, Lotrel, and Diovan/HCT for the high blood pressure, Gemfibrozil for slightly elevated cholesterol (I cannot take statins), Actos, and Metaformin for diabetes. I recently started physical therapy treatments for the lymph edema. The PT said that the HCT (HydroCloroThyazide) component of the Diovan is a diuretic which I remember being put on to help treat the Lymph edema. One of the side effects is elevated blood sugar.
The most recent such analysis was published last month and suggested Avandia is more likely to cause strokes and heart-related death than a rival drug, Actos, made by Japan-based Takeda Pharmaceuticals. The paper's chief author, Dr. David Graham, an FDA scientist who wants the pill banned, estimated as many as 100,000 heart-related problems may have been caused by Avandia. The study analyzed medical records of more than 225,000 elderly Medicare patients.
For my money it's all tied together, the thyroid pancreas and pituitary are all part of the endocrine system, they all go downhill with this disease, producing a complex variety of dysfunctions, IR being definitely among them. And lets not even get into the heart and brain changes or we will really depress everybody. yet facts remain facts: It's time we recognized this disease is taking a toll on not just many but most of our major glands and organs.
Rushed back to hospital on June 10 with severe chest pains. Angiogram showed OK. Still had chest pains. October 2002 had mild heart attack and another stent was placed. Before the surgery his heart stopped for 7 seconds. After stent more chest pains but stress test was OK. Chest pains even with time release nitro. Angiogram in Jan 2003 showed first stent was blocked. They did Brachy procedure. Two weeks later I found him lying on ground gasping with chest pain.
We know the polycystic ovary syndrome is associated with increased risk of heart attack and stroke because of the associated heart attack and stroke risk factors, hypertension, obesity, hyperandrogenism, hypertriglyceridemia, and these are to a large degree resolved by therapy with these medications. ARE THESE MEDICATIONS SAFE? Side effects are rare.
We could have added more Metformin, and Actos, and then perhaps resorted finally to insulin, or, we could try this. Time will tell if we made the right decision, but my sugar levels are saying, for now at least, that we made the right one. What I would like to learn here is if there have been any serious side affects (besides pancreatitis which I already know about) in people since the studies were documented in the med insert.
We know the polycystic ovary syndrome is associated with increased risk of heart attack and stroke because of the associated heart attack and stroke risk factors, hypertension, obesity, hyperandrogenism, hypertriglyceridemia, and these are to a large degree resolved by therapy with these medications.
there's no amount of SSRIs that will take away a cardiovascular problem, and PPIs might kill off heart burn, but it won't make angina go away. In my opinion, heart pain and heart burn do not feel anything like each other. Right now, there are a few meds that help combat small vessel angina. Long acting nitroglycerin, calcium channel blockers, ARBs, and maybe betas. Betas help relax the heart and lower bp, but have some drawbacks in treating this condition.
Klor-Con 10 [potassium supplement]; Digoxin 0.25 mg (heart); Indomethacin 25 mg daily (headaches - Rx by Neurologist); and Zonisimide 100 mg once daily); Flomax .4 mg (once daily); and Lasix 20 mg. (once daily). Needless to day, despite our group insurance and his Medicare our pharmacy bill (copays) is more than the mortgage payment each month. I would think that all these meds might also have a bearing on his symptoms, but have never seen anything addressing this.
I spoke with my parents and found out that my 82 year old father has had this problem his whole life, and takes nothing, and has never had a heart attack, I asked him how he could stand it because when I listened to his heart it was palpitating constantly, he said I have just learned to live with it...
I also have a fatty liver I treated fatty liver with ACTOS And blister went away for 2 years now they are back and I need to take more ACTOS
We were given the option to wait another month and not go forward or go forward and take the chance. My heart told me to go forward. They did the sperm wash and his count was 90 million, and no white blood cells. I felt this was he hope we needed. I felt crampy the night after the IUI, the next day still cramping and some pinching, day 3 after IUI still mild cramping and pinching, day 4 after still cramping and pinching. I too am so afaraid of the dreaded negative result.
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