I have had very little problems with Prolia. I've done 4 injections over the past 2 years. Just a little bit of bone pain for the first 2 wks after the injection then, it goes away. That said, unfortunately, for me, my DEXA did not improve and my osteoporosis in my spine (the T-score) did not get better. Now, my doctor is sending me to a 'bone' clinic that apparently specializes in bone disorders such as osteoporosis.