Insomnia, mania, and mixed episodes drove me crazy for years. Seroquel was the drug that finally kicked the worst of it. I had been on Zyprexa, Risperdal, Abilify, & Geodon, as well as Lamictal and Lithium and countless sleep drugs and sedatives. Seroquel isn't perfect, but it is magic for me compared to all of the other drugs I've been on. We're now adding in some Tegretol to see if it can make things even better. My husband - also bipolar - takes Seroquel too.